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About This Simulation
Step into the virtual classroom to learn the secrets behind the electrophilic aromatic substitution. Explore the mechanism of this reaction, the effects of activating and deactivating groups, and the stability of the different resonance structures. Can you help create the perfect perfume?
Learning Objectives
- Understand the mechanism of the EAS
- Classify substituents of benzene as activating or deactivating and as ortho, meta, and para directing groups
- Recognize resonance structures to explain the outcome of any EAS
About This Simulation
Lab Techniques
Related Standards
- US College Year 2
- US College Year 3
Learn More About This Simulation
Can you help create a best-selling scent? Perfumes are everywhere — and so are aromatic compounds. In this simulation, you will learn about the electrophilic aromatic substitution, answer a variety of quiz questions, and then plan the synthesis of your favorite aromatic compound!
Understand the mechanism
If you’re making a perfume, electrophilic aromatic substitution is a key reaction when synthesizing an aromatic molecule of interest. You’ll start your experience in a pharmacy to learn about vanillin. Then you’ll be teleported to the virtual classroom to start your experience. Here, you’ll learn in an interactive way about the mechanism of the reaction, choosing the direction of movement of electrons and the key reagents.
Choose activators and deactivators
Once you’re familiar with the reaction on a benzene ring, you’ll move to the effects of directing groups when combining an electrophile with a mono substituted benzene ring. You’ll place the different substituents on a reactivity graph and choose the right product of reaction so that you’ll be able to characterize a substituent as an activator or deactivator and predict the correct products.
The stability of resonance structures
Understanding the mechanism is not enough when planning a synthetic route. In this activity you’ll have to connect the different resonance structures of a mono substituted benzene attacked by an electrophile with the concept of stability, to help predict the dominant structure at the end of the reaction.
A real perfume-maker
Now that you’ve acquired all this knowledge, you’re ready to go into a real lab and plan the synthesis of your favorite aromatic compound. Will you create the new best-selling perfume?
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A Labster virtual lab is an interactive, multimedia assignment that students access right from their computers. Many Labster virtual labs prepare students for success in college by introducing foundational knowledge using multimedia visualizations that make it easier to understand complex concepts. Other Labster virtual labs prepare learners for careers in STEM labs by giving them realistic practice on lab techniques and procedures.
Labster’s virtual lab simulations are created by scientists and designed to maximize engagement and interactivity. Unlike watching a video or reading a textbook, Labster virtual labs are interactive. To make progress, students must think critically and solve a real-world problem. We believe that learning by doing makes STEM stick.
Yes, Labster is compatible with all major LMS (Learning Management Systems) including Blackboard, Canvas, D2L, Moodle, and many others. Students can access Labster like any other assignment. If your institution does not choose an LMS integration, students will log into Labster’s Course Manager once they have an account created. Your institution will decide which is the best access method.
Labster is available for purchase by instructors, faculty, and administrators at education institutions. Purchasing our starter package, Labster Explorer, can be done using a credit card if you are located in the USA, Canada, or Mexico. If you are outside of North America or are choosing a higher plan, please speak with a Labster sales representative. Compare plans.
Labster supports a wide range of STEM courses at the high school, college, and university level across fields in biology, chemistry, physics, and health sciences. You can identify topics for your courses by searching our Content Catalog.