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About This Simulation
Learn about the monogenic disorder Cystic Fibrosis and its inheritance from one generation to the next.
Learning Objectives
- Understand the basic concepts of inheritance
- Build and interpret a pedigree based on family data
- Understand genetic risk assessment and counselling
- Understand the work of a genetics laboratory
About This Simulation
Lab Techniques
- Gel electrophoresis
- Capillary electrophoresis
- PCR
Related Standards
- HS-LS3-1
- HS-LS3-2
- HS-LS3-3
- No direct alignment
- 3.4 Inheritance
Learn More About This Simulation
Cystic Fibrosis is a type of monogenic disorder caused by a mutation in both copies of the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator).
Learn about Cystic Fibrosis
The CTFR gene encodes a protein that regulates the movement of chloride ions in and out of cells that produce mucus, sweat, saliva, or tears. Cystic Fibrosis is also called mucoviscidosis because patients suffer from thickened mucus. People with one mutated copy of the CFTR gene are called carriers and do not experience any symptoms.
Patients with Cystic Fibrosis
Cystic Fibrosis is the most common autosomal recessive disease among Europeans. It is characterized by allele heterogeneity, meaning that CFTR genes from many different patients with Cystic Fibrosis show different type of mutations. The most common alteration in the CFTR gene is a deletion of three nucleotides, resulting in a loss of the amino acid phenylalanine (F) at position 508 in the protein, and is hence called ΔF508.
Apply your knowledge
In the Monogenic Disorders lab, you will learn about the monogenic disorder Cystic Fibrosis and its inheritance from one generation to the next. You will also learn how a single gene mutation leads to a dysfunctional, disease-causing protein.
Will you be able to consult a young couple on the potential risk for their future children to develop Cystic Fibrosis?
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For Science Programs Providing a Learning Advantage
North Dakota State College of Science
“They did the simulation at home, then completed the in-person lab within 30 minutes, no questions asked, and passed the quiz with flying colors.”
Lecturer in Human Physiology
University of Westminster
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Modesto City Schools
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Wenatchee Valley College
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San José State University
"We surveyed over 400 students. More than 90% thought Labster was easy to navigate, and that it was fun, but more importantly, most of them felt confident that they could execute the labs in person. And that confidence is a big deal."
FAQs
Find answers to frequently asked questions.
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Labster supports a wide range of courses at the high school and university level across fields in biology, chemistry and physics. Some simulations mimic lab procedures with high fidelity to train foundational skills, while others are meant to bring theory to life through interactive scenarios.