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About This Simulation
Learn about the function and principles of ion exchange chromatography and get hands-on experience by purifying a protein involved in Parkinson’s disease to help study the relation between the protein and the disease.
Learning Objectives
- Set up the apparatus required and follow the general workflow associated with liquid chromatography
- Detail the concept behind compound separation by size exclusion
About This Simulation
Lab Techniques
- Ion-exchange column chromatography
Related Standards
- Early Stage Bachelors Level
- EHEA First Cycle
- FHEQ 6
- Intermediate Stage Bachelors Level
- US College Year 1
- US College Year 2
- US College Year 3
- US College Year 4
- Chemistry Unit 3.9
- Chemistry B.2
Learn More About This Simulation
This short, targeted simulation is adapted from the full-length Parkinson’s Disease simulation.
How to purify the protein sample to obtain a high purity compound? Now you have the opportunity to learn one of the techniques that can do that! In the Ion Exchange Chromatography simulation, you will learn what chromatography is and you will perform your own purification experiment.
Prepare the protein sample
First step in chromatography is the preparation of the sample. Therefore, in the beginning you will extract monomers of alpha synuclein (aSN), a protein that is involved in the development of Parkinson’s disease. In order to do so, you will use sonication to extract the protein, which is produced by an E. coli bacterial strain.
Perform ion-exchange chromatography
Next step is the purification of the extracted aSN monomers by ion exchange chromatography. First, you will learn about the different parts of the chromatography equipment to get familiar with them and then you will apply your knowledge and run the experiment yourself!
Analyze the results and pick the right fraction
Finally, you will analyze the chromatogram and find the fraction that has our purified aSN protein. Your work will help the researchers in their further study. Maybe your contribution will help us find a cure for Parkinon’s disease?
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A Labster virtual lab is an interactive, multimedia assignment that students access right from their computers. Many Labster virtual labs prepare students for success in college by introducing foundational knowledge using multimedia visualizations that make it easier to understand complex concepts. Other Labster virtual labs prepare learners for careers in STEM labs by giving them realistic practice on lab techniques and procedures.
Labster’s virtual lab simulations are created by scientists and designed to maximize engagement and interactivity. Unlike watching a video or reading a textbook, Labster virtual labs are interactive. To make progress, students must think critically and solve a real-world problem. We believe that learning by doing makes STEM stick.
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Labster supports a wide range of STEM courses at the high school, college, and university level across fields in biology, chemistry, physics, and health sciences. You can identify topics for your courses by searching our Content Catalog.