MAGE Virtual Lab
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About the MAGE Virtual Simulation Lab
Multiplex automated genome engineering (MAGE) is a recombinant engineering tool for large-scale programming and accelerated evolution of cells. Before MAGE was introduced by George Church, scientists would painstakingly edit one gene at a time, examine the phenotype changes, and start the whole process again. MAGE is fast and efficient, cheap, and highly scalable. In addition, it allows researchers to edit specific or random sites in the genome and it also operates continuously in vivo. MAGE’s main limitation on the other hand lies on its portability. It has been exclusively used in E.coli so far.
In the Multiplex Automated Genome Engineering (MAGE) lab, you will learn how to edit the genome of Escherichia coli in order to enhance the beta-carotene metabolic pathway that was previously inserted. You will design the oligos according to the technique requirements, perform different MAGE cycles, and screen the resulting clones. Will you be able to enhance the beta-carotene metabolic pathway to increase its production in E. coli?
How it works
A million dollar lab in your browser
You can now perform advanced experiments to achieve core science learning outcomes. Theory and practise is connected in a novel way, and all you need is a computer/laptop and a browser!
Our simulations run even on older laptops and computers, and you will be able to play our simulations without having to install any browser plugins.
See detailed minimum requirements here.
100s of hours of science learning content
Explore many different science topics at your pace and difficulty level.
Our virtual laboratory simulations are aimed at university, college and high school level, within fields such as Biology, Biochemistry, Genetics, Biotechnology, Chemistry, Physics and many more.
With unlimited access to more than 60 different full simulations, you will have hundreds of hours of fun, innovative and high quality learning content available to you.
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