Stereochemistry: From stereocenters to E/Z isomers (NEW)

Time to complete course: 20 min.

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About Stereochemistry: From stereocenters to E/Z isomers (NEW) Virtual Lab Simulation

From 2D sketches to 3D molecules

In this simulation, you’ll first be guided through the theory behind isomers and chiral centers, just to make sure you are familiar with these topics. Then, our friendly Dr. One will move your attention to 3D structures of stereoisomers and will need your help to solve some tasks.  Here, you’ll be asked to recognize chiral and achiral molecules, rotate them and even break a couple of bonds (don’t worry, we have good insurance). 

As you get used to the 3D visualization, the complexity of the molecules will increase, and your understanding will be tested through quizzes and tasks.

Prioritize the groups in different enantiomers

Once the concept of stereoisomerism has been introduced, you will learn how to assign the relative configuration of enantiomers through prioritization rules. This is fundamental to understanding R and S configurations and by looking at some artistic posters, we’ll be able to make it less tricky and a bit more intuitive.

Once you grasp the concept, Dr. One will test you using the 2D representation often used in the theory books, but we’ll add some feedback and animation depending on your answers.

Identify Cis/Trans or E/Z isomers

The next step will be to distinguish between cis and trans isomers. To do so, a visual game on the main screen of the laboratory will suggest six different molecules, and you’ll decide whether they are cis or trans. 

Finally, after an introduction to E and Z isomers, you’ll be asked to identify three new molecules before the final quiz.

Get Started Now

Take a deep dive into the world of molecules: discover how they are structured and understand how their spatial arrangement can make all the difference in their physical and chemical properties.
Stereochemistry concerns the structure and shape of molecules in three dimensional space. The positions and connections of atoms in molecules can affect their properties, that’s why stereochemistry is crucial in the introduction to organic chemistry
However, using only your imagination to visualize these 3D structures can be tough, especially if you’ve just started your journey into this topic.

Techniques in Lab

  • Concept-based simulation

Learning Objectives

  • Identify stereogenic centers in chiral molecules and understand the definition of enantiomers
  • Differentiate between chiral and achiral molecules
  • Differentiate between cis/trans and E/Z isomers
  • Assign R or S configuration to enantiomers applying Cahn-Ingold-Prelog priority rules

Simulation Features

Length – 20 minutes
Accessibility mode – Available
Languages – English

Examples of Related Standards


1st year chemistry related


PS1.A, HS-PS2-6


Chemistry 20.3: Stereoisomerism


Chemistry Unit 2.7: VSEPR and Bond Hybridization

Screenshots of Stereochemistry: From stereocenters to E/Z isomers (NEW) Virtual Lab Simulation


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