Action Potential Lab: Experiment with a squid neuron Virtual Lab

Dissect a squid and use its giant neuron to witness the propagation of information in the shape of an action potential created by an electric current. Use this information to identify a neurotoxin affecting a hospitalized patient.

  • University / College
Watch video

Labster is used by 1000s of amazing schools and universities

Learn more

About This Simulation

Did you know that nerve cells propagate an electric signal along their own membrane to transfer information? They are called action potentials, and in this simulation you will use a squid’s giant neuron to learn about the molecular mechanisms behind this phenomenon. You will learn to recognize the typical shape of an action potential, but also to describe the driving forces behind each of its different phases.

Identify a neurotoxin from its effect on a nerve

In this simulation your mission is to help out a hospital who just received a patient with severe food poisoning. A sample from the patient has revealed the presence of a neurotoxin, and they need you to identify it as soon as possible. To find out how, you will first dissect a giant squid to extract the neuron to use as a model, and then study the neuron membrane with electric currents. Once you understand how action potential works on the membrane of a neuron, you will compare the effect of existing neurotoxins with your sample for identification.

Observe and test a neuron with electric currents

To study the axon of a nerve, you will reproduce the historically famous experiment of Dr Hodgkin and Dr Huxley, which was rewarded with a Nobel Prize, by setting the neuron in a test chamber to trigger action potentials with electric currents. You will learn about ion flows and calculate the resulting membrane equilibrium and membrane potential. Using the current clamp and voltage clamp techniques, you will identify the mechanisms behind each stage of an action potential. Once you have a good grasp of the concept of membrane potentials, you will be transported inside an axon to define the precise chain of actions leading to an action potential. Finally, you will test three different neurotoxins and analyze their effects on action potentials to deduce their most probable mode of action.

Identify the neurotoxin by its mode of action

To uncover which neurotoxin affects the hospitalized patient, you will have to compare its effect on the neuron’s action potential with three other drugs, and come up with a hypothesis about how it deregulates the neuron’s ability to transmit a signal.

Will you be able to help out the sick patient?

Explore Action Potential Lab: Experiment with a squid neuron Virtual Lab Simulation

APL Screenshot 1
APL Screenshot 2
APL Screenshot 3
APL Screenshot 4

How do virtual labs work?

Engage students in science through interactive learning scenarios. Simulate experiments, train lab techniques, and teach theory through visual experiences that enhance long-term learning outcomes.

  • 250+ Web-based simulations that can be played on laptops and tablets without installing any software

  • Teacher dashboard to automate grading and track student progress

  • Embedded quizzes to help students master science content

  • Library of learning resources, lab reports, videos, theory pages, graphics and more

Get started now!
You can explore and assign simulations to your students right away.

  • Access to over 250 Labster simulations for free.
  • Exclusive educator access to all of Labster Course Manager content.
  • 30 days for free, no credit card needed.
  • Invite your students to play simulations and get their feedback.
course manager

Integrate with your LMS

Labster integrates with all major LMS (Learning Management Systems) so that educators can use their gradebooks to track students’ performance data and students can keep a record of their work. Labster is compatible with Canvas, Blackboard, Moodle, Google Classroom, Schoology, Sakai, and Brightspace / D2L. It’s also possible to use Labster without an LMS.

Learn more