Learn about the Mendelian inheritance of double muscling in cattle. Find the responsible gene using linkage analysis and learn how mutation in this gene alters gene expression resulting in double muscled cattle.
- University / College
About This Simulation
In the Animal Genetics simulation you will learn about Mendelian inheritance and how a mutation in DNA can give rise to an altered phenotype. You will use polymerase chain reaction (PCR) and gel electrophoresis to perform genotyping in order to identify the gene that causes double muscling in cattle.
Fill in the pedigree
As a researcher you will be called to a farm to investigate a case about double muscled cattle. In your first task you will fill in a pedigree to help identify the double muscled cattle. By studying the pedigree, you will learn about heritable traits and whether double muscling is autosomal or sex-linked and whether it is dominant or recessive. You will then draw a blood sample, and from that, extract DNA and perform further experiments in the lab.
Identify the candidate gene
Your next task will be to perform genome scanning, which involves an analysis of the entire genome and identifying the candidate gene by using short tandem repeats (STRs) as markers. By detecting STR patterns and similar gene sequences in double muscled cattle DNA, your goal will be to narrow down the genomic location of the candidate gene. Experimentally, this will be achieved by amplifying the STRs using PCR and analyzing the PCR product size using gel electrophoresis.
Develop a DNA test
After identifying the gene responsible for double muscling, your last task will be to develop a DNA test. This test will be used to determine the origin of organic meat; as it is prohibited to label meat as organic if derived from double muscled cattle. You will use your newly developed DNA test on three meat packages from an organic farm.
Will you be able to use your understanding of animal genetics to find the gene which causes double muscling and develop a reliable commercial test for organic meat?
Explore Animal Genetics Virtual Lab Simulation
How do virtual labs work?
Engage students in science through interactive learning scenarios. Simulate experiments, train lab techniques, and teach theory through visual experiences that enhance long-term learning outcomes.
250+ Web-based simulations that can be played on laptops and tablets without installing any software
Teacher dashboard to automate grading and track student progress
Embedded quizzes to help students master science content
Library of learning resources, lab reports, videos, theory pages, graphics and more
Get started now!
You can explore and assign simulations to your students right away.
- Access to over 250 Labster simulations for free.
- Exclusive educator access to all of Labster Course Manager content.
- 30 days for free, no credit card needed.
- Invite your students to play simulations and get their feedback.
Integrate with your LMS
Labster integrates with all major LMS (Learning Management Systems) so that educators can use their gradebooks to track students’ performance data and students can keep a record of their work.