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Antibodies: Why are some blood types incompatible? Virtual Lab

Learn about the concepts of antibodies and antigens, as well as the ABO and Rhesus blood grouping systems and their importance in blood transfusions. Then, you will help a young couple determine a potential risk for Rhesus disease in their unborn child.

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Antibodies: Why are some blood types incompatible?

About this Simulation

Even though antibodies are proteins that protect us from harmful intruders, they can sometimes cause problems. In this simulation, you will examine blood samples from a mother and her unborn child, to determine whether or not they are compatible.

Learn the basics of antibodies

Examine the actual 3D molecular structure of antibodies on the holotable and observe an immersive animation to understand the basics of antibody-antigen interaction and the mechanism that lies behind rhesus incompatibility.

Perform a blood type test

Follow the steps of an Eldon test to determine what blood groups are found in several patient test samples. Discover what antigens and antibodies have to do with blood type, and learn why mixing certain different blood types together can cause problems.

Apply your knowledge

In the end, put all this knowledge to the test by performing the Eldon test on the mother and her unborn child and interpret the results. Will you be able to help the young couple and their child?

Learning Objectives

At the end of this simulation, you will be able to:

  • Understand the structure and function of antibodies (different isotypes and parts of an antibody)

  • Understand the formation of the antibody-antigen complex

  • Name the four major blood types (phenotypes) in the ABO system

  • Explain the principles of blood typing using Eldon cards

  • Describe Rhesus incompatibility and hemolytic disease

Techniques in Lab

At the end of this simulation, you will be able to:

  • Blood Typing

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