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Next Generation Sequencing
Learn the different steps of sample preparation, sequencing, data collection and data analysis using next generation sequencing technique.

About This Simulation

In the NGS Simulation students obtain a hair sample from an ancient Greenland man, extract his DNA, and perform DNA sequencing. The NGS technology uses second-generation DNA sequencing, where users perform sequencing of many samples at the same time, also known as massive parallel sequencing. NGS has many real –life application scenarios. Specifically, this lab will use SNP (Single Nucleotide Polymorphism) analysis to correlate the result with physical appearance such as hair baldness, earwax thickness and many others. By looking at the SNP result, students can reconstruct the physical appearance of the ancient Greenland man.



Dr. Simon Rasmussen

Center for Biological Sequence Analysis, Department of System Biology

Technical University of Denmark

Learning Objectives

  • Understanding the different steps in sample preparation, cluster generation, sequencing and data processing
  • Learning the characteristic of ancient DNA
  • Learning that Single Nucleotide Polymorphism (SNP) can be tightly correlated to a specific physical feature


  • Next generation sequencing


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