Sensory transduction: Learn why you feel pain when you get hit by a rock

Sensory transduction
Time to complete course: 37 min.

About Sensory transduction: Learn why you feel pain when you get hit by a rock Virtual Lab Simulation

How do anesthetic drugs work? In this simulation, you will learn the basics of sensory transduction by testing and comparing the mechanisms of action of two anesthetic drugs. Explore which stimuli activate different types of sensory neurons and behold the flow of ions inside an axon. Perform a patch-clamp experiment to analyze how the anesthetics impact the pain transduction in the nociceptors, and confirm the results by performing some in vivo experiments before selecting the best pain killer for your friend.

Explore sensory neurons

Which neurons are activated when you get a cut? What about when you are hit by a rock? Explore the different types of sensory neurons on the holo-table and see the impact of six different stimuli as many times as you want! Then, figure out which stimuli activate nociceptors to transduce pain, and dive into an axon to learn which transmembrane receptor makes nociceptors sensitive to pain and the flow of ions inside.

Set up your own patch-clamp experiment

You will dissect some dorsal root ganglia from a rat’s spinal cord to use for a patch clamp experiment. You will set up the equipment and use different buffers to conduct the voltage-clamp experiment. You will then be able to see and analyze the results on the virtual PC screen in a short time, avoiding long waiting times in between changes of buffers, and allowing you tol test the effect of the two anesthetics to evaluate their effect on the flow of ions and in sensory transduction.

Confirm your results with an in vivo model

After analyzing the in vitro data, you will determine if the differences in the effect of the two pain killers are confirmed in in vivo studies. This includes conducting latency to withdrawal experiments and analyzing motor function experimental results. You will finally dive one last time into the axon to see the effect of each anesthetic drug inside the nociceptors. Will you be able to determine which drug is best to give your injured friend?

Get Started Now

Learn the basic mechanisms of sensory transduction by performing in vitro and in vivo experiments and determine which anesthetic drug will allow your friend to keep climbing a mountain without having the muscles affected.

Techniques In Lab

  • Voltage-clamp method
  • Latency to Withdrawal

Learning Objectives

At the end of this simulation, you will be able to…

  • Understand the types of sensory neurons and their responses to different stimuli
  • Describe the response of a sensory receptor to chemical stimuli at the cellular and organismal level
  • Set up a voltage-clamp experiment, and measure and interpret changes in current in response to chemical stimuli
  • Analyze and interpret patch clamp results to contrast how two sodium channel blockers inhibit capsaicin-induced excitability
  • Collect data and analyze it on withdraw reflex time in an acute pain model

Screenshots of Sensory transduction: Learn why you feel pain when you get hit by a rock Virtual Lab Simulation

Collaborators

Dr. Jon Harrison

School of Life Sciences
Arizona State University

How it works

A million dollar lab in your browser

Perform experiments in virtual lab simulations to achieve core science learning outcomes. 

All our simulations run on laptop and desktop computers, and you can play our simulations without having to install any browser plugins.

See detailed minimum requirements here.

Hundreds of hours of science learning content

Our virtual laboratory simulations are aimed at university, college and high school level, within fields such as biology, biochemistry, genetics, biotechnology, chemistry, physics and more.

With access to our simulations, you will have hundreds of hours of engaging, high-quality learning content available to you.

Discover more Virtual Lab Simulations

We currently have 159 simulations that cover everything from biology and medicine to physics and chemistry.

Learn how you can use Labster in your science course

Discover how to use Labster in your program course

Over 150+ simulations that cover everything from biology to physics and chemistry.

Take a 15 Minute “Lab Break” with a Virtual Lab Expert

Talk to one of our Virtual Lab Experts about how Labster can engage your students with our virtual labs for online, hybrid and face-to-face courses.

Lab break coffee with us

Please fill out the form below to talk with one of our Lab Experts. 


You must opt in to receive emails from Labster. You can unsubscribe at any time.
Thank you for your submission!

Labster Product Tour

Wednesdays: 1PM ET (US) | 10AM PT (US)

Days
Hours
Minutes

The simulation is already added to this package

Step 1: Choose your simulations

Find and select the simulations that you want to add to your course.

Step 2: Review simulation list

This is the list of simulations that will be added to your course. Click Download once you are ready.

%%%selected_title%%%
No simulations added yet.
    %%%selected_title%%%
    Download the .zip file and upload it to your LMS.

    Download Common Cartridge File

    Choose your Learning Management System below:
    Generating download link. Please wait...
    Congratulations! You can now upload the .zip file into your LMS by the following these instructions:

    Simulation name

    Image container

    Learning Outcomes

    Learning outcomes container

    Techniques

    Techniques container

    Simulation Description

    Description container

    Are you sure you want to delete?

    Package deleted successfully

    IMPORTANT: Check the original email with instructions from your instructor to verify how you should gain access.

    Link Access

    Did you receive a link/URL to access Labster from your teacher? This is for either “Labster Direct” or “Quick Access”, and no login is required. See info below.

    School LMS

    Are you accessing Labster from your school’s LMS, such as Canvas, Blackboard, Moodle or Brightspace? Click below to read more.

    Course Code

    Did you receive a Course Code from your teacher? (this is different from a purchased voucher code. Learn how to access the Labster LMS, or log in below.
    IMPORTANT: Please check your original email to confirm the correct access option.

    Labster Direct / Quick Access

    Did you receive a link/URL to access simulations through the Labster Direct or Quick Access pages? If so, no login is required. See info below.

    Your LMS

    Are you accessing Labster from your school’s LMS, such as Canvas, Blackboard, Moodle or Brightspace? Click below to read more.

    edX

    Are you accessing Labster directly from the Labster.com edX LMS? View more information here or click the button below to log in.

    Faculty Resources

    To access the Faculty Resources page (instructors only) and review Labster simulations, please log in below.