.png?fm=jpg "Treatment for Chronic Kidney Disease")
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About This Simulation
Synthesize a treatment for anemia in patients with chronic kidney disease. Examine the protein sequence to understand the differences between protein synthesis in prokaryotes and eukaryotes.
Learning Objectives
- Understand how the hormone EPO is related to chronic kidney disease
- Synthesis proteins in E. coli and CHO cells
- Compare the synthesis of proteins in E. coli and CHO cells
- Interpret mass spectrometry histograms
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About This Simulation
Lab Techniques
- Protein synthesis
- Mass spectrometry
Related Standards
- Early Stage Bachelors Level
- Early Stage Masters Level
- EHEA First Cycle
- FHEQ 6
- Intermediate Stage Bachelors Level
- Late Stage Bachelors Level
- US College Year 1
- US College Year 3
- US College Year 2
- US College Year 4
- No direct alignment
- No direct alignment
- Biology 2.7 DNA replication, transcription and translation
- Biology 3.5 Genetic modification and biotechnology
Learn More About This Simulation
This shorter, targeted simulation is adapted from the full-length “Protein Synthesis” simulation.
Discover a treatment for anemia in patients with chronic kidney disease. In this simulation, you will learn about the difference between protein synthesis in prokaryotic cells (using E. coli) and eukaryotic cells (using CHO cells). Analyze your samples using mass spectrometry to find out which cells are better for synthesizing a treatment.
Chronic kidney disease
Start your mission with a 3D animation explaining the purpose of kidneys and the effects of chronic kidney disease on the body. Learn how anemia can be caused by the disease and how erythropoietin (EPO) affects the production of red blood cells. Review your knowledge of protein synthesis and make a hypothesis before you start your research into a possible treatment. Which cells will perform better?
Prepare the erythropoietin samples
Your first task in the lab will be to prepare recombinant human erythropoietin (rhEPO) that is transfected into E. coli and CHO cells. Prepare the two samples inside the biosafety cabinet then take the samples to the incubator. In a virtual lab we can speed up the incubation time so this step takes seconds instead of hours. Our helpful lab assistant will purify the samples while you review the synthesis of rhEPO with quiz questions.
Use mass spectrometry to analyze your samples
Prepare your samples for analysis. You will measure the mass to charge ratio of the two rhEPO samples using a mass spectrometer. Explore the histograms then answer questions about your results. Can you work out which cells are better for the production of erythropoietin? Was your hypothesis correct?
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For Science Programs Providing a Learning Advantage
North Dakota State College of Science
“They did the simulation at home, then completed the in-person lab within 30 minutes, no questions asked, and passed the quiz with flying colors.”
Lecturer in Human Physiology
University of Westminster
"I saw some of the students who clearly didn’t necessarily like sitting there reading a book discover they could turn on Labster and keep up with the rest of the class because it spoke to them.
Modesto City Schools
"Having something that's engaging for the students gives teachers that opportunity to breathe and get excited again. Because they're seeing the kids light up, they're seeing the kids engage with content."
Wenatchee Valley College
"The question always is, ‘Can we demonstrate that the students are meeting course outcomes?’ Check! We can do that.”
San José State University
"We surveyed over 400 students. More than 90% thought Labster was easy to navigate, and that it was fun, but more importantly, most of them felt confident that they could execute the labs in person. And that confidence is a big deal."
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FAQs
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A Labster virtual lab is an interactive, multimedia assignment that students access right from their computers. Many Labster virtual labs prepare students for success in college by introducing foundational knowledge using multimedia visualizations that make it easier to understand complex concepts. Other Labster virtual labs prepare learners for careers in STEM labs by giving them realistic practice on lab techniques and procedures.
Labster’s virtual lab simulations are created by scientists and designed to maximize engagement and interactivity. Unlike watching a video or reading a textbook, Labster virtual labs are interactive. To make progress, students must think critically and solve a real-world problem. We believe that learning by doing makes STEM stick.
Yes, Labster is compatible with all major LMS (Learning Management Systems) including Blackboard, Canvas, D2L, Moodle, and many others. Students can access Labster like any other assignment. If your institution does not choose an LMS integration, students will log into Labster’s Course Manager once they have an account created. Your institution will decide which is the best access method.
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Labster supports a wide range of STEM courses at the high school, college, and university level across fields in biology, chemistry, physics, and health sciences. You can identify topics for your courses by searching our Content Catalog.