Nucleophilic Addition: Explore the Grignard Reaction

Nucleophilic Addition
Time to complete course: 52 min.

Access 160+ virtual learning simulations

Discover which Labster plan is right for your institution

About Nucleophilic Addition: Explore the Grignard Reaction Virtual Lab Simulation

Addition reactions are one of the greatest tools in a medicinal chemists’ toolkit! In this simulation, you will learn the principles of the nucleophilic addition reaction and put your knowledge into practice by performing a Grignard reaction to synthesize a potential cancer drug candidate. You’ll have the chance to make a ground-breaking drug discovery!

Last-ditch drug discovery

Join scientists in a drug discovery team as they investigate one last hunch before the failing project is shut down. Students will get hands-on in exploring the nucleophilic addition reaction in a pharmaceutical research lab, and apply their knowledge to help synthesize a molecule with therapeutic potential. To transform the existing ketone into the target alcohol, students will develop their practical and theoretical knowledge of the Grignard reaction.

Nucleophilic addition – experiment and explore!

Interact with nucleophilic addition reaction components at a molecular level with our 3D reaction visualizer. Identify important reaction components before triggering the electron flow to carry out the reaction before your eyes! Get up close with the mechanistic principles of nucleophilic addition and better acquainted with molecular-level reactivity considerations.

You’ll also have the chance to give a Grignard reaction a go in a safe and instructive lab environment. Synthesize your moisture-sensitive Grignard reagent in situ before using it directly in a Grignard reaction to get one step closer to your target molecule. Prompts from Dr. One will remind you of the tricky practical aspects to remember for a successful Grignard reaction!

Pharmaceutical scale-up

To complete the simulation you’ll investigate factors you’ll need to consider in scaling up the Grignard reaction to an industrial scale if the drug is shown to be a ‘hit’. Will you be able to design a synthesis for an effective treatment for breast cancer?

Get Started Now

Assist scientists on a drug discovery project and learn how to use nucleophilic addition to transform organic molecules into life-saving drugs! Will you be able to synthesize a new pharmaceutical product using the Grignard reaction?

Techniques in Lab

  • Reflux technique
  • Air- and moisture-sensitive synthesis
  • Synthesis and use of Grignard reagents in-situ

Learning Objectives

At the end of this simulation, you will be able to…

  • Demonstrate a detailed understanding of the nucleophilic addition reaction
  • Provide an overview and examples of nucleophilic addition to a carbonyl group
  • Draw correctly the mechanism for common nucleophilic addition reactions
  • Demonstrate a detailed understanding of the Grignard reaction
  • Describe the role of each reagent in the Grignard reaction
  • Explain the sensitivity of Grignard reaction conditions and be able to make procedural adjustments
  • Gain understanding and practical experience of essential laboratory techniques:
    • Reflux reactions
    • Air-sensitive synthesis
    • Generation and use of reagents in situ

Simulation Features

Length – 52 minutes
Languages – English

Examples of Related Standards

University

Chemistry related 1st year onwards

NGSS

No direct alignment

IB

No direct alignment

AP

No direct alignment

Screenshots of Nucleophilic Addition: Explore the Grignard Reaction Virtual Lab Simulation

Collaborators

How it works

A million dollar lab in your browser

Perform experiments in virtual lab simulations to achieve core science learning outcomes. 

All our simulations run on laptop and desktop computers, and you can play our simulations without having to install any browser plugins.

See detailed minimum requirements here.

Hundreds of hours of science learning content

Our virtual laboratory simulations are aimed at university, college and high school level, within fields such as biology, biochemistry, genetics, biotechnology, chemistry, physics and more.

With access to our simulations, you will have hundreds of hours of engaging, high-quality learning content available to you.

Discover more Virtual Lab Simulations

We currently have 200 simulations that cover everything from biology and medicine to physics and chemistry.

Learn how you can use Labster in your science course

NEW LEARNING CONTENT!

38 new Virtual Lab Simulations – Lab Reports – Library of Science Images  – New 3D Science Animations – and more… 

Take a 15 Minute “Lab Break” with a Virtual Lab Expert

Talk to one of our Virtual Lab Experts about how Labster can engage your students with our virtual labs for online, hybrid and face-to-face courses.

Lab break coffee with us

Please fill out the form below to talk with one of our Lab Experts. 


You must opt in to receive emails from Labster. You can unsubscribe at any time.
Thank you for your submission!

Sales Demo: Discover how Labster
improves student grades and learning outcomes!

Limited to 100 people

The simulation is already added to this package

Step 1: Choose your simulations

Find and select the simulations that you want to add to your course.

Step 2: Review simulation list

This is the list of simulations that will be added to your course. Click Download once you are ready.

Press the + button next to the simulations that you want to add to your list, or add all the simulations of this package by pressing “add all simulations”.

%%%selected_title%%%

Related Simulations

No simulations added yet.
    %%%selected_title%%%
    Download the .zip file and upload it to your LMS.

    Download Common Cartridge File

    Choose your Learning Management System below:
    Generating download link. Please wait...
    Congratulations! You can now upload the .zip file into your LMS by the following these instructions:

    Simulation name

    Image container

    Learning Outcomes

    Learning outcomes container

    Techniques

    Techniques container

    Simulation Description

    Description container

    Are you sure you want to delete?

    Package deleted successfully

    IMPORTANT: Check the original email with instructions from your instructor to verify how you should gain access.

    Link Access

    Did you receive a link/URL to access Labster from your teacher? This is for either “Labster Direct” or “Quick Access”, and no login is required. See info below.

    School LMS

    Are you accessing Labster from your school’s LMS, such as Canvas, Blackboard, Moodle or Brightspace? Click below to read more.
    IMPORTANT: Please check your original email to confirm the correct access option.

    Labster Direct / Quick Access

    Did you receive a link/URL to access simulations through the Labster Direct or Quick Access pages? If so, no login is required. See info below.

    Your LMS

    Are you accessing Labster from your school’s LMS, such as Canvas, Blackboard, Moodle or Brightspace? Click below to read more.

    Faculty Resources

    To access the Faculty Resources page (instructors only) and review Labster simulations, please log in below.