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Cytogenetics

In the Cytogenetics lab, you will learn about techniques that are used in prenatal diagnostic, chromosomal disorders and the consequences for the unborn child.

About This Simulation

Students begin this lab in an ultrasound examination room where a young mother-to-be receives an abnormal ultrasound result. Students must find the underlying cause and inform the couple about possible outcomes of their unborn child and future children.

In order to find the underlying cause, students need to perform array CGH using an amniocentesis sample. Students learn the basic principles of array CGH and how to analyze their result. In order to confirm findings, students are required to perform karyotyping for both the fetus and parents. Students learn how to prepare amniocentesis and blood sample for karyotyping and how to analyze their results.

Based on the results and information collected during counseling with the parents; students conclude the underlying cause of the fetus abnormality. Students must explain the fetus’ medical condition and advise the parents in future circumstances.

Screenshots

Collaborators

Dr. Anne Nørremølle

Dr. Anne Nørremølle

Department of Cellular and Molecular Medicine

University of Copenhagen

Dr. Iben Bache

Dr. Iben Bache

Department of Cellular and Molecular Medicine

University of Copenhagen

Dr. Asli Silahtaroglu

Dr. Asli Silahtaroglu

Department of Cellular and Molecular Medicine

University of Copenhagen

Dr. Søs Marie Luise Bisgaard

Dr. Søs Marie Luise Bisgaard

Department of Cellular and Molecular Medicine

University of Copenhagen

Learning Objectives

  • Learning about medical genetic counseling especially in the case of prenatal diagnostics
  • Understanding and performing array Comparative Genome Hybridization (array CGH)
  • Understanding and performing karyotyping
  • Understanding how manifestation can be linked to underlying syndromes that are inherited from the parents

Techniques In This Simulation

  • Array comparative genomic hybridization
  • Karyotyping
  • Amniocentesis
  • Pedigree analysis

Collaborator

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