Gene Regulation Virtual Lab

Time to complete course: 54 min.Need help? Visit our Help Center.

About the Gene Regulation Virtual Lab Simulation

In the past, there was no hope for visually impaired people to regain their sight back. Welcome to the future of medicine! In this simulation, you will learn the gene regulation principle that won the Nobel Prize for Physiology 2012. With the gene regulation technique develop by Sir Gurdon and Shinya Yamanaka, your mission is to try to treat a visually impaired girl.

Learn the basics of stem cells

In order to save the visually impaired girl, you will prepare induced pluripotent stem cells (iPS) from a fibroblast cells sample taken from the girl. The iPS cells will then be differentiated to retinal-pigmented epithelial cells for transplantation. In this simulation, 3D-animations will allow you to take a closer look at the machinery involved in gene regulation. You will learn about the basics of stem cells and what it takes to create one.

Transform fibroblast cells into iPS cells

You will have to determine which transcription factors are essential in maintaining a stem cell’s features based on what you have learned in the previous mission. After determining the genes, you will use a retroviral infection technique to transform mature fibroblast into iPS cells. After incubation, you will examine which set of transcription factors is capable of inducing the fibroblast into stem cells (iPS).

Analyze gene expression

By now you will have an idea of which transcription factor is capable of transforming fibroblast cells into iPS cells. The next step is to confirm your findings by analyzing the gene expression in mRNA and protein level. You will perform reverse transcription PCR (RT-PCR) and Western blot to investigate the mRNA and protein level, respectively. Finally, you will have to decide which set of transcription factors can be used to transform fibroblast cells into iPS effectively. Will you be able to help the girl?

Get Started Now

Open your eyes to the vast potential of gene regulation, where you can reprogram cells into any cell that fits your needs. Will you able to help the doctor in restoring the sight of a visually impaired girl?

Techniques In Lab

  • Microscopy
  • RT-PCR
  • Western blot

Learning Objectives

At the end of this simulation, you will be able to…

  • Explain how gene expression can be regulated
  • Describe the different levels of gene regulation (mRNA and protein)
  • Measure mRNA levels (RT-PCR), protein expression (Western blotting)

Screenshots of Gene Regulation Virtual Lab Simulation

Collaborators

Dr. Mette Voldby Larsen

Dr. Mette Voldby Larsen

Institute of Systems Biology

Denmark Technical University

Dr. Jose MG Izarzugaza

Dr. Jose MG Izarzugaza

Center for Biological Sequence Analysis

Technical University of Denmark

How it works

A million dollar lab in your browser

You can now perform advanced experiments to achieve core science learning outcomes. Theory and practice is connected in a novel way, and all you need is a computer/laptop and a browser!

Our simulations run even on older laptops and computers, and you will be able to play our simulations without having to install any browser plugins.

See detailed minimum requirements here.

100s of hours of science learning content

Explore many different science topics at your pace and difficulty level.

Our virtual laboratory simulations are aimed at university, college and high school level, within fields such as Biology, Biochemistry, Genetics, Biotechnology, Chemistry, Physics and many more.

With unlimited access to more than 60 different full simulations, you will have hundreds of hours of fun, innovative and high quality learning content available to you.

Study faster with the best award-winning science education tool

Learn anytime, anywhere.

Learn anytime, anywhere.

Labster is a 24/7 state-of-the-art virtual lab at your disposal. Study and learn at your own pace from anywhere.

Money back guarantee.

Money back guarantee.

Unlimited access to your own million dollar laboratory for just $19 per month. Full money back guarantee for your first paid month.

A million dollar lab on your laptop.

A million dollar lab on your laptop.

Turn your laptop into a lab-top with unlimited access to Labster’s fast-growing, immersive blended-learning experience. We offer 60+ simulations.

Trusted and used by top universities globally

What students think about Labster:

"A very innovative, immersive learning experience. It allows you to be more confident before going to the real laboratory. It's mind-blowing!"

Alice

Alice

Student Ambassador at Exeter Uni

"A great way to learn, because it can be very hard if you are just taught the theory - here you can try it yourself."

Ellie

Ellie

Student Ambassador at Exeter Uni

"More people should know about this! Some students don't really like science and this tool is amazing to get students passionate about science by making it fun and easy to learn."

Lucy

Lucy

Student Ambassador at Exeter Uni

FAQ

Frequently Asked Questions

I'm using Labster as part of my course. Do I need to buy a subscription?

If you are enrolled in a class and instructed by your teacher to use Labster, please make sure you use the sign-up information that has been provided by your teacher. Otherwise, they will not be able to follow your progress and achievements, and you may need to purchase a license twice.

How many simulations will I get access to?

You will get unlimited access to all our simulations. We release new simulations nearly every month, and you can always see an overview of all our simulations in our simulation catalog.

When will my account renew?

Your subscription will renew automatically each month after the free trial is over, unless you have made a single simulation purchase.

How can I cancel my subscription?

If you would like to unsubscribe, please use this form. An automated confirmation email will be sent out to you in the next few minutes. Click the confirmation link contained in the email in order to finalize the termination of your subscription.

What are the minimum requirements for my computer?

You can find an overview of the minimum requirements here.