Regeneration Biology

Check out how some vertebrates are able to regrow entire limbs and explore the cellular mechanisms behind tissue regeneration in cute axolotls using microscopy and fluorescent proteins.

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  • Description
  • Features

Regeneration sounds like a superpower, but some reptiles and amphibians are perfectly able to regrow entire parts of their bodies. In the Regeneration Biology simulation, you get to dissect axolotls and observe the cells responsible for the restoration of missing limbs under the microscope.

Grasp the cellular mechanisms behind tissue regeneration

You will join Dr. Prometheus in his research to learn why some wounds can regenerate and others cannot, and how it translates into different treatments in a medical ward. You will experiment with axolotls in the Regeneration Biology lab to discover the critical steps required for regeneration to occur and learn about the cellular particularities of the blastema.

Tissue analysis and fluorescent constructs

In the Regeneration Biology lab, you will be able to virtually dissect axolotls and observe the regeneration process in a few minutes instead of weeks. In that way, you can experiment with different conditions, for example suturing a wound, and immediately see how it affects the tissues – all without harming any real animals. Using a microscope, you will also analyze the tissue samples from a regenerating stump to identify the involved cell types. Finally, you will use fluorescent proteins to explore the concept of positional information and its importance in regenerative biology through the creation of mutant axolotls.

Apply the data from axolotls to humans

You will apply your newly acquired knowledge of regeneration biology to understand the current treatments for open wounds and the possibilities for the future of medicine.

Will you be able to figure out why humans cannot regenerate as well as some other vertebrates?

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Check out how some vertebrates are able to regrow entire limbs and explore the cellular mechanisms behind tissue regeneration in cute axolotls using microscopy and fluorescent proteins.

Techniques in lab
Microscopy, Fluorescent proteins, Dissection
Learning objectives

At the end of this simulation, you will be able to...

  • Understand that the ability to regenerate tissues varies throughout vertebrates
  • Describe what a blastema is and the cell types that compose this structure
  • Understand the concept of positional information in regenerative biology
Simulation features

Length: 34
Accessibility mode: Not available
Languages: English (United States)

NGSS

No direct alignment

IB

High level content, may support 1.1 Introduction to cells

AP

No direct alignment