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Regeneration Biology Virtual Lab

Regeneration Biology

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Check out how some vertebrates are able to regrow entire limbs and explore the cellular mechanisms behind tissue regeneration in cute axolotls using microscopy and fluorescent proteins.

About the Regeneration Biology Virtual Simulation Lab

Regeneration sounds like a superpower, but some reptiles and amphibians are perfectly able to regrow entire parts of their bodies. In the Regeneration Biology simulation, you get to dissect axolotls and observe under the microscope the cells responsible for the restoration of missing limbs.

Grasp the cellular mechanisms behind tissue regeneration

You will join Dr. Prometheus in his research to learn why some wounds can regenerate and others cannot, and how it translates into different treatments in a medical ward. You will experiment with axolotls in the Regeneration Biology lab to discover the critical steps required for regeneration to occur and learn about the cellular particularities of the blastema.

Tissue analysis and fluorescent constructs

In the Regeneration Biology lab, you will be able to virtually dissect axolotls and observe the regeneration process in a few minutes instead of weeks. This way you can rapidly experiment with different conditions, for example suturing a wound, and immediately see how it affects the tissues – all without harming any real animals. Using a microscope, you will also analyze the tissue samples from a regenerating stump to identify the involved cell types. Finally, you will use fluorescent proteins to explore the concept of positional information and its importance in regenerative biology through the creation of mutant axolotls.

Apply the data from axolotls to humans

You will apply your newly acquired knowledge of regeneration biology to to understand the current treatments for open wounds at the hospital and the possibilities for the future of medicine.

Will you be able to figure out why humans cannot regenerate as well as some other vertebrates?

Techniques In Lab

  • Dissection
  • Microscopy
  • Fluorescent proteins

Learning Objectives

At the end of the simulation, you will be able to…

  • Understand that the ability to regenerate tissues varies throughout vertebrates
  • Describe what a blastema is and the cell types that compose this structure
  • Understand the concept of positional information in regenerative biology

Screenshots of Regeneration Biology Virtual Simulation Lab

Collaborators

Prof. Malcolm Maden

Prof. Malcolm Maden

Biology department

University of Florida

Prof. Brian Harfe

Prof. Brian Harfe

Associate Dean, College of Liberal Arts and Sciences

University of Florida

Emma Brady

Emma Brady

Senior Instructional Designer

UF Online

How it works

A million dollar lab in your browser

You can now perform advanced experiments to achieve core science learning outcomes. Theory and practise is connected in a novel way, and all you need is a computer/laptop and a browser!

Our simulations run even on older laptops and computers, and you will be able to play our simulations without having to install any browser plugins.

See detailed minimum requirements here.

100s of hours of science learning content

Explore many different science topics at your pace and difficulty level.

Our virtual laboratory simulations are aimed at university, college and high school level, within fields such as Biology, Biochemistry, Genetics, Biotechnology, Chemistry, Physics and many more.

With unlimited access to more than 60 different full simulations, you will have hundreds of hours of fun, innovative and high quality learning content available to you.

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