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Tissue Engineering

In this simulation you will help a sports physician repair athletes’ damaged articular cartilage.
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About This Simulation

In the Tissue engineering simulation, you will help a sports physician repair athletes’ damaged articular cartilage. During your quest, you will learn the principle of hydrogel synthesis and its application in regenerative medicine. Will you manage to produce a suitable hydrogel to replace the damaged cartilage?

Screenshots

Tissue Engineering simulation
Tissue Engineering fridge
Glutamine and Lysine
rheology - storage modulus measurement

Collaborators

Prof. Dr. Marcy Zenobi-Wong, Assistant Professor

Prof. Dr. Marcy Zenobi-Wong, Assistant Professor

Department of Health Sciences and Technology

ETH Zurich

Mischa Müller, PhD student

Mischa Müller, PhD student

Cartilage Engineering and Regeneration

ETH Zurich

Learning Objectives

  • Understanding the basic principle of tissue engineering
  • Learning about articular cartilage injuries and their treatment using hydrogels
  • Understanding types of crosslinking to synthesize hydrogels:
    • Radical crosslinking
    • Ionic crosslinking
    • Enzymatic crosslinking
    • Michael addition crosslinking
  • Analyzing the synthesized hydrogels’ mechanical properties using rheology

Techniques

  • Ionic crosslinking
  • Radical crosslinking
  • Michael addition crosslinking
  • Enzymatic crosslinking
  • Rheology

Collaborator

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